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KMID : 1036920170220020102
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Annals of Pediatric Endocrinology & Metabolism
2017 Volume.22 No. 2 p.102 ~ p.107
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Intellectual development in preschool children with early treated congenital hypothyroidism
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Seo Min-Kyoung
Yoon Jong-Seo
So Chul-Hwan
Lee Hae-Sang
Hwang Jin-Soon
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Abstract
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Purpose: Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH.
Methods: We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence.
Results: The patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76?126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0?9.9 μg/kg/day) and 22 with a high dose of levothyroxine (10.0?16.0 μg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis.
Conclusion: IQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment.
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KEYWORD
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Congenital, Hypothyroidism, Intellectual disability, Synthyroid
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